Radu Marian Serban¹, Nicolai Craciun¹², Constantin Munteanu³, Diana Munteanu³ͯ, Gheorghe Stoian¹
1 University of Bucharest, Dept. of Biochemistry & Molecular biology, Bucharest, Romania
2 Ecological Society for Research and Conservation of Wild Flora and Fauna “Aquaterra” Romania
3 Biosafety SRL, Romania
4 National Institute of Rehabilitation, Physical Medicine and Balneoclimatology, Bucharest, Romania Corresponding authors:firstname.lastname@example.org; email@example.com
Electromagnetic radiation is an important factor that has a powerful influence on the organisms. Different types of radiation have different effects, while some are harmless; the ones that have high energy can determine major changes at a molecular level.
In order to protect themselves, many classes of algae developed different defense mechanisms, through biosynthesis of a family of compounds named mycosporine like amino acids (MAA). This MAA are capable of absorbing UV type radiation, protecting the more sensitive molecule of the cells and literature data show that these compounds have the capacity to protect human skin cells against UV rays of solar radiation.
The aim of this study was to determine if the MAA were able to protect mammalian cells against X-rays, an electromagnetic radiation with higher energy then UV. The radioprotection was tested using Wistar mouse fibroblast cells cultures by placing between them and the source of the radiation (between 78.37 and 173 Sv/h) an agarose gel who contains different concentrations of an alcoholic extract obtained from Ceramium genus of red algae. Viability tests and metalloproteinase profile have indicated that X-ray protection of the fibroblast culture depends on the intensity of the x-ray and the concentration of red algae extract from agarose gel.
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